From my reading, natural interventions to boost HGH (testosterone is also a common one) seem to be short lived; an initial spike followed by the body trying to achieve homeostasis.
''We found that exercise induces distinct GH bursts after 30 min followed by increased STAT5b phosphorylation after 90 min and increased IGF-I mRNA expression after 270 min. This sequence is in full accordance with studies showing that exogenous GH administration leads to rapid initial STAT5 activation followed by IGF mRNA after some hours (9, 10, 15). Recently one study (14) has shown increased STAT5 phosphorylation 30 min after exercise in humans. The study, however, did not include a control situation without exercise, and it is uncertain whether a needle biopsy per se may increase stress hormone levels (16).Fasting is characterized by complex enhancement of GH pulse frequency and amplitude and decreased blood concentrations of IGF-I (11). Our design did not capture distinct synchronous GH bursts in the eight individuals studied, so it is not surprising that we only observed a tendency toward increased STAT5 phosphorylation. In addition to the ups and downs of disorderly GH secretion, increased levels of FFAs may inhibit STAT5 phosphorylation (17). It is all the more striking that IGF-I mRNA expression in muscle remained elevated in both biopsies after 72 h of fasting, and the expression may be addressed to the overall elevated GH level. Data on GH signal transduction during fasting are sparse. One study has shown decreased STAT5 phosphorylation after a GH bolus during fasting (13), but the study did not include direct assessment of the effects of fasting, and the finding of decreased GH activation of STAT5 could relate to FFA inhibition of phosphorylation (17).''
Yup, I still have to avoid heelhooks.
It is all the more striking that IGF-I mRNA expression in muscle remained elevated in both biopsies after 72h if fasting, may be addressed to the overall elevated GH level.
Not sure most people would think of missing breakfast once or twice a week as fasting, I do that by accident most weeks!
No idea if it will be helpful for your particular knee issue, but if you can ignore the silly name, 'knees over toes guy' on YouTube seems to be the place to go for advice on working towards healthy knees. Many people have allegedly avoided surgery by doing the things he recommends.
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