Vurt is probably my favourite sci-fi book: lyrical prose, a great sense of place (a remixed Manchester) and a real feeling of poignancy, unusual for the genre. I would avoid the follow-up (Pollen) though, personally found it to be an utterly unreadable experiment with language at the complete expense of clarity and plot.
I really liked both Vurt and Pollen - well worth reading.
All time classic recommendation: The Great Gatsby by F Scott Fitzgerald. Just staggeringly beautifuly written - and the only one of his books where I had any sympathy whatsoever for one of his characters (as far as I can tell the rest of his stuff revolves around wealthy, unpleasant types who are drunks as an alternative to working - rather than because of it).
The best book i ever read is the 1989 Stanage guide.
Off the sci-fi, the best new'ish book I've read for years is probably Cloudwritten by David Mitchell - several interwoven stories set mainly in the far east. Clever and great fun - it absolutely flew by (which surprised me as I normally find Booker prize type stuff to be a bit onerous). You also get to painlessly learn a bit about Japan, and China's cultural revolution along the way... which is nice.
I can recommend anything by:- Carl Hiaasen- Kinky Friedman- Hemingway (esp Old Man and The Sea, and Farewell to Arms)- Garcia Marquez (esp Love in a Time of Cholera)- Hunter S Thompson (esp Fear and Loathing in Las Vegas, and Great Shark Hunt)