UKBouldering.com

SCIENCE!!! (Read 125757 times)

petejh

Offline
  • *****
  • forum hero
  • Posts: 5778
  • Karma: +622/-36
#400 Re: SCIENCE!!!
November 30, 2020, 08:51:04 pm
Wow..

Takeover by the machines etc. etc.

How long before AI discovers alcohol and girls/boys and it all goes downhill...

tomtom

Offline
  • *****
  • forum hero
  • Posts: 20282
  • Karma: +641/-11
#401 Re: SCIENCE!!!
November 30, 2020, 09:33:30 pm
After its cracked grading :D

mrjonathanr

Offline
  • *****
  • forum hero
  • Posts: 5377
  • Karma: +242/-6
  • Getting fatter, not fitter.
#402 Re: SCIENCE!!!
November 30, 2020, 09:48:14 pm
I know nothing of protein folding; anyone care to explain?

Sounds impressive. However, I doubt AI could solve the riddle of the Olympic qualifying system tbh

jwi

Online
  • *****
  • forum hero
  • Posts: 4219
  • Karma: +331/-1
    • On Steep Ground
#403 Re: SCIENCE!!!
November 30, 2020, 10:19:47 pm
Briefly then, amino acids makes up the primary structure of a protein. When e.g. a gene have coded a protein the primary structure folds i three dimensions. This happens incredibly fast, on a time scale of micro seconds. We (humans) have only very foggy ideas how this is done in nature. Alas, the exact structure of a folded protein has biological function — so to explain or predict the biological function of a protein we need to know how it is folded. Usually this is determined by some pretty involved experimental methods, and has to be done for each protein.

In the best of all worlds we would be able to quickly determine a protein's exact structure just from the gene that codes for the protein. Just as our cells do.

That's my understanding anyway. I have done very little work in computational biology and in a fairly unrelated field so I am sure that someone else here can supply a better explanation.
« Last Edit: November 30, 2020, 10:28:37 pm by jwi »

mrjonathanr

Offline
  • *****
  • forum hero
  • Posts: 5377
  • Karma: +242/-6
  • Getting fatter, not fitter.
#404 Re: SCIENCE!!!
November 30, 2020, 11:36:47 pm
Interesting, helpful summary. Thanks.

remus

Offline
  • *****
  • forum hero
  • Posts: 2857
  • Karma: +146/-1
#405 Re: SCIENCE!!!
December 01, 2020, 07:00:56 am
I know nothing of protein folding; anyone care to explain?

Sounds impressive. However, I doubt AI could solve the riddle of the Olympic qualifying system tbh

The press release on the deepmind website is surprisingly good https://deepmind.com/blog/article/alphafold-a-solution-to-a-50-year-old-grand-challenge-in-biology

teestub

Offline
  • *****
  • forum hero
  • Posts: 2575
  • Karma: +166/-4
  • Cyber Wanker
#406 Re: SCIENCE!!!
December 01, 2020, 07:49:40 am

The press release on the deepmind website is surprisingly good

As you’d expect, imagine how many press releases it analysed before writing that one! 🤖

jwi

Online
  • *****
  • forum hero
  • Posts: 4219
  • Karma: +331/-1
    • On Steep Ground
#407 Re: SCIENCE!!!
December 27, 2020, 11:19:28 am
Reverse engineering the source code of the Biontech/Pfizer vaccine.

https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/

I think this article is pretty accessible to anyone who knows either a bit of informatics or a bit of biology, or are willing to spend some time reading, thinking and following the links with further explanation. Time well spent imho.

Falling Down

Offline
  • *****
  • forum hero
  • Posts: 4880
  • Karma: +333/-4
    • bensblogredux
#408 Re: SCIENCE!!!
December 27, 2020, 12:24:31 pm

tomtom

Offline
  • *****
  • forum hero
  • Posts: 20282
  • Karma: +641/-11
#409 Re: SCIENCE!!!
January 14, 2021, 09:47:56 am
In a break from generally bad news in the world - this is clever!

Invasive Snake species in Guam make themselves into lasso's to climb trees. (watch the video!)

https://www.cell.com/current-biology/fulltext/S0960-9822(20)31763-2




JamieG

Offline
  • *****
  • forum hero
  • Posts: 1278
  • Karma: +80/-0
#410 Re: SCIENCE!!!
January 14, 2021, 11:05:26 am
Very cool. The locomotion part, not the invasive species part.

Fultonius

Offline
  • *****
  • forum hero
  • Posts: 4315
  • Karma: +138/-3
  • Was strong but crap, now weaker but better.
    • Photos
#411 Re: SCIENCE!!!
January 31, 2021, 06:57:49 pm
Any HVAC engineers in the house?

I've not done anything on HVAC since uni, but have a decent understanding. We've been up at my mum's since mid December, it's a >250yr old house with a kitchen that has 3.5 outside walls!

We've been working on a fair few comfort improvements - after the old raeburn was removed in the kitchen the chimney never was, and it was leaking, whistling and geenrally sucking all the heat out, so this summer she got the stack removed and roof re-slated over it. But, it was still open to the loft and we could see condensation on the roof/rafters etc. I capped it off and added some insulation, and that's made a big difference.

She also got a thermostat for the heating for the first time, and we blocked off some vents in the larder which were also just sucking out heat.

So, after all we've got the heating down to being being 8-10 hours per day, instead of the 14 we had before and most rooms are more comfortable. No condensation or damp issues (still a leaky house), but the kitchen is still 2 degC colder than the thermostat (and noticeably less comfortable). The windows are all double glazed, the loft is insulated and the cavity walls are filled (good, bad...hmm...they are).

So, my thinking is that it's just "under-heated" - it's only got one, fairly average sized, radiator convection central heater.  I've got some brand new 80mm PC fans (spare from a project that fizzled out) and thinking of rigging up a simple air-flow booster to the radiator. What I'm wondering is....would the effectiveness of the fans be much higher if the system was somewhat "ducted", or would you get sufficient benefit from them just pulling through additional air in the "zone of influence" of the fans?

I'm almost temped to rig up an arduino to log temps and do some trials....

SA Chris

Offline
  • *****
  • forum hero
  • Posts: 29221
  • Karma: +630/-11
    • http://groups.msn.com/ChrisClix
#412 Re: SCIENCE!!!
February 17, 2021, 03:03:51 pm

bigironhorse

Offline
  • ****
  • junky
  • Posts: 767
  • Karma: +16/-0
    • YouTube
#413 Re: SCIENCE!!!
March 03, 2021, 04:30:16 pm
https://www.bbc.com/news/in-pictures-56238018

Well the bouldering looks great. Count me in on the first manned mission  :strongbench:

Wood FT

Offline
  • *****
  • forum hero
  • Posts: 2951
  • Karma: +162/-8
#414 Re: SCIENCE!!!
March 03, 2021, 04:45:38 pm
What are the gravity cons?

Oldmanmatt

Offline
  • *****
  • forum hero
  • At this rate, I probably won’t last the week.
  • Posts: 7097
  • Karma: +368/-17
  • Largely broken. Obsolete spares and scrap only.
    • The Boulder Bunker climbing centre
#415 Re: SCIENCE!!!
March 03, 2021, 05:01:52 pm
What are the gravity cons?
Pretty good, but the weight of your rebreather, helmet et al, might off set that a little.
Grimer is already adding a chapter into his next book.

.....You’ll  definitely need a brush...

tomtom

Offline
  • *****
  • forum hero
  • Posts: 20282
  • Karma: +641/-11
#416 Re: SCIENCE!!!
March 03, 2021, 05:26:19 pm
Cold. Gravity 1/3 of what it is here. Rock type - mainly basalt - some water some wind carved.

A few 1-2km vertical (old water fall) faces to climb up.

Possibly a fair bit of choss too :)

teestub

Offline
  • *****
  • forum hero
  • Posts: 2575
  • Karma: +166/-4
  • Cyber Wanker

 

SimplePortal 2.3.7 © 2008-2024, SimplePortal